FAQ-2974
What is the nature and target of the Internal Control supplied with Certal Residual DNA Detection Kits?
The Internal Control supplied with Certal Residual DNA Detection Kits is a non-linearized plasmid (naked nucleic acid).
The Internal Control supplied with Certal Residual DNA Detection Kits has an artificial sequence that is not present in biological sample material.
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Certal Residual DNA Detection Kits
When working with biopharmaceuticals, it is essential to evaluate the final therapeutic material to ensure that it is free of contaminating substances, such as residual DNA from the host cell. Certal Residual DNA Detection Kits are designed for sensitive and rapid real-time PCR quantification of residual host cell genomic DNA using dual-labeled hydrolysis (also known as TaqMan®) probes. The Certal CHO Detection Kit contains reagents for duplex real-time PCR detection of CHO residual host cell DNA, plus the Certal Internal Control. The kit also includes the Certal Residual DNA Positive Control, which verifies the functionality of the PCR assay in the absence of a signal from CHO host cell DNA, and 2 formats of ROX passive reference dye in different concentrations, enabling use on virtually any real-time instrument.