Syndromic Testing

Reliably detect central nervous system infections with QIAstat-Dx

Get the answer when it matters most

Infections of the central nervous system (CNS) – meningitis and encephalitis – require immediate medical attention. To provide timely therapeutic care for a patient with a CNS infection, you need an accurate diagnosis within hours. But identifying the causative pathogen, whether bacterial, viral or fungal, can be challenging. Traditional diagnostic tools, like cerebrospinal fluid culture and Gram stain, can be labor intensive, time-consuming and show limited sensitivity1,2. 

Syndromic testing offers a rapid diagnostic solution for CNS infections. The QIAstat-Dx Meningitis/Encephalitis Panel provides comprehensive results in about an hour, ensuring the most serious infections won’t go missed.

Meningitis moves fast
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you must too

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Over 2.8 million cases of bacterial meningitis occur globally each year3
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A delay in antibiotic treatment is a strong and independent risk factor for mortality, even after just 6 hours4,5
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Without treatment, the case-fatality rate for bacterial meningitis can be as high as 70%6
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28% of community-acquired episodes of bacterial meningitis result in one or more neurologic complications7

Traditional methods alone can’t cut it

48 hours

It can take up to 48 hours for pathogen identification using CSF culture1

Less than 60%

The sensitivity of Gram stain for bacterial meningitis is only around 60%1

20% decrease

The sensitivity of culture and Gram stain may decrease by 20% if antibiotic treatment has occurred1

Only 24%

Only 24% of patients with meningitis show abnormal findings with a CT scan2
Female doctor in conversation with male older patient

Deliver accurate results faster with syndromic testing

  • Reduces time to microbiological diagnosis by 3.3 days8
  • Reduces length of stay by 2.2 days8,9
  • Reduces length of antimicrobial use by up to 3 days and overall inappropriate antimicrobial use8–10
  • Simple enough to perform in a variety of settings, including community and rural hospitals11

Learn more about the QIAstat-Dx Meningitis/Encephalitis Panel

The QIAstat-Dx ME Panel offers results for 15 bacterial, viral and fungal pathogens in around an hour. When used in combination with traditional microbiology methods, the QIAstat-Dx ME Panel can help guide diagnoses and treatment decisions to help save lives. Learn more about the panel in our brochure.
Get the brochure
QIAstat-Dx Meningitis/Encephalitis (ME) Panel

QIAstat-Dx ME Panel detects 15 common targets that cause CNS infections

Microbial gDNA isolation
Bacterial
Escherichia coli K1
Haemophilus influenzae
Listeria monocytogenes
Neisseria meningitidis (encapsulated)
Streptococcus agalactiae
Streptococcus pneumoniae
Mycoplasma pneumoniae
Streptococcus pyogenes
Viral
Enterovirus
Herpes simplex virus 1 
Herpes simplex virus 2
Human herpes virus 6
Human parechovirus
Varicella zoster virus
Fungal

Cryptococcus neoformans/gattii*

*Cryptococcus neoformans/Cryptococcus gattii are both detected, but not differentiated
References
  1. Van de Beek D. et al. (2016) Cli Microbiol Infect. 22, S37–S62
  2. Hasbun R. et al. (2001) N Engl J Med. 345(24), 1727–1733
  3. GBD 2016 Meningitis Collaborators. (2018) Lancet. 17,1061–1082
  4. Auburtin M. et al. (2006) Crit Care Med. 34(11), 2758–2765
  5. Proulx, N., et al. (2005) QJM. 98(4), 291–298
  6. Rosenstein N.E. et al. (2001) N Engl J Med. 344, 1378–1388
  7. Durand M.L. et al. (1993) N Engl J Med. 328(1), 21–28
  8. Cailleaux M. et al. (2019) ) Eur J Clin Microbiol Infect Dis. 39, 293–297
  9. Moffa M.A., et al. (2020) Antibiotics (Basel). 9(6), 282
  10. Posnakoglou L. et al. (2020) Eur J Clin Microbiol Infect Dis. 39, 2379–2386
  11. Leber A. et al. (2016) J Clin Microbiol. 59(4), 2251–2261

 

Data cited pertains to the use of a device from another manufacturer.

The QIAstat-Dx Analyzer is intended for in vitro diagnostic use. 

The QIAstat-Dx ME Panel is indicated as an aid in the diagnosis of specific agents that cause meningitis and/or encephalitis, and results must be used in conjunction with other clinical, epidemiological, and laboratory data. Results from the QIAstat-Dx ME Panel are not intended to be used as the sole basis for diagnosis, treatment, or other patient management decisions. Positive results do not rule out co-infection with organisms not included in the QIAstat-Dx ME Panel. The agent or agents detected may not be the definite cause of the disease. Negative results do not preclude central nervous system (CNS) infection. 

The QIAstat-Dx ME Panel is intended for in vitro diagnostic use by laboratory professionals only.

Product availability may differ from country to country based on regulations and approvals. Contact your country representative for further details.