LNA Technology

Detect and discriminate short or closely related sequences with ease

LNA oligos exhibit unprecedented thermal stability when hybridized to their complement. This much higher affinity – compared to traditional DNA or RNA oligos – helps overcome the difficulties of studying very short sequences. LNA oligos have greatly improved, and in many cases enabled, specific and sensitive detection of non-coding RNA and other small RNA molecules. Beyond RNA, these powerful tools are ideal for detecting low-abundance, short or highly similar targets in many other research applications. QIAGEN provides a comprehensive portfolio of LNA-enhanced research tools. Read on and learn how you can use these to gain more insights from your experiments.

The Power of LNA
The Power of LNA
LNA tools have unprecedented sensitivity and specificity – ideal for challenging applications, in which the target is present at low levels
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Custom LNA Oligonucleotide Design and Applications
Custom LNA Oligonucleotide Design and Applications
Learn how to create custom LNA-enhanced oligos for applications not covered by our standard products
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LNA Application Stories
LNA Application Stories
LNA enhancement enables powerful analyses in many different research applications – see what others are doing
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Gene Expression Analysis
Gene Expression Analysis
Choose between SYBR Green or an LNA-enhanced hydrolysis probe for detection
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miRNA Quantification
miRNA Quantification
Extremely sensitive and specific miRNA quantification, with a fast and easy workflow – even for samples with low RNA content
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RNA/miRNA Sequencing
RNA/miRNA Sequencing
Reaction chemistries and simplified workflows for preparing robust NGS libraries and eliminating PCR and sequencing bias
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RNA/miRNA Function Studies
RNA/miRNA Function Studies
Unique and innovative designs ensure high potency and target specificity to help you discover new RNA functions in vitro and in vivo
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RNA/miRNA Localization
RNA/miRNA Localization
Superior binding affinity enables differentiation of splice variants, isoforms and small mutations with an exceptionally high signal-to-noise ratio
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LNA Resource Center
LNA Resource Center
The unique characteristics of LNA make it a powerful tool, not only for miRNA research but also for detection of low-abundance, short or highly similar targets in a number of applications.
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Antisense LNA GapmeR Custom Builder Help
Antisense LNA GapmeR Custom Builder Help
The Antisense LNA GapmeR Custom Builder will help you create and purchase antisense oligonucleotides for effective and specific knockdown of your RNA target.
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